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Studies have shown the benefits of vitamin B6 in relieving edema and reducing water retention, improving magnesium deficiency, peripheral neuropathy, carpal tunnel syndrome, tendonitis, rheumatism, cardiovascular occlusions and myocardial infarcts, learning and developmental disorders, and autism.
Technically, vitamin B6 is an umbrella term given to three different vitamins, pyridoxine, pridoxal, and pyridoxamine. The three B6 vitamins work together with other enzymes to speed up chemical reactions in cells.
Those processes include making amino acids, creating neurotransmitters like serotonin and metabolizing energy released in creating red blood cells. Vitamin B6 benefits also include helping to balance hormones and strengthen the immune system.
About your goldenseal ordeal....
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Taking too much goldenseal for a lengthy amount of time may lead to problems of the digestive tract, including constipation and diarrhea. It may also trigger extreme states of stress, and in some cases delirium hallucinations. It could cause some of the issues that it is intended to aid with if taken for too long a time.
--- and that's the problem with a lot of things I think. They become toxic in your system as they build up over the long haul.