I think your last post hit it. Use an AR shooting supersonic ammo. Less over penetration issues. 300 blackout seems like a lot for home defense. Subsonic 300 blackout will go through rail road ties. I wouldn't want to shoot it in the house, terminal performance not withstanding.
I 3 loaded firearms in the house. an AR loaded with 5.56 suppressed, 9mm subsonic, and a 12 gauge. I am building a 300 blackout but i wouldn't use it in that role.
If a large number of people are willing to kill you for saying something, than it probably really needs to be said. Charlie Hebdo wasn't the first and it won't be the last, but freedom of expression is worth the risk and the sacrifice.