Whatever you can run easily, especially if it's intuitive to run bleary-eyed in the dark, works. I like the ability to run ambidextrous, which dictates a lot of where I tend to run WML's, but there are some great trainers that run some stuff that to me initially would be weird (see Kyle Defoor's TLR-3 preferred setup).
Again, primary consideration is can you run the gun and manage recoil well, then from that hand position how can you actuate a light intuitively without altering that grip: this is why there are so many options, and why it's a good idea to try a bunch of options until something just works.
[For my part, I run 12:00 mounting on all my lights: usually an X300 in front of DD Fixed Front sight or FSB; or a SF Scout/VTAC L4 Scout setup ran in the same spot with offset irons]
عندما تصبح الأسلحة محظورة, قد يملكون حظرون عندهم فقط
کله چی سلاح منع شوی دی، یوازي غلوونکۍ یی به درلود
Semper Fi
"Being able to do the basics, on demand, takes practice. " - Sinister
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