Going to shoot a bull on a buddy's ranch next weekend. Probably will also take deer with the same rifle/load.

There was a time when I would have bought into the standard Safari goer suggestion of 375 H&H, or a .338 Win Mag. But I'm not doing that. I will take the .300 Win Mag but I don't load for belted magnums yet, so I'm stuck with factory ammo. The 165gr. Barnes TTSX and 200gr. ELD-X in Hornady Precision Hunter are the loads I own and that I know shoot well.

Will the lighter Barnes bullet hold up better/penetrate better than the heavier ELD-X?

I'm not worried about either with good shots, but heat a lot about a "dermal plate" on these animals that can supposedly cause problems combined with their thick hide.

Suggestions? Experiences?