Instant one shot incapacitation:
Physiologically, the only way to reliably produce this effect with a pistol is to put a hole in the brain or spinal cord. Caliber does not appear to matter, within reason, as long as it can reach and penetrate those areas.
Psychologically, instant one shot incapacitation is unreliable, but also seems to be independent of caliber.
If we eliminate the instant and single shot part, more shots faster looks better by my math. There continues to be no evidence showing that .45 drops crappy people faster than 9mm.
Plan on using more than one round. Caliber seems to be the least important factor in the outcome of a pistol fight.
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