I know it would be expensive, but certainly there is a market for a gas-sealed threaded muzzle revolver.

A modernized Nagant revolver if you will.

Suppressed .38 ammo would be extremely common, quiet and reliable. No moving barrel to cause reliability issues, no moving parts to create noise, action stays locked until you pull the trigger again.

I think at $1000 they'd sell. A little more for a big-bore.

.22LR, , .32, .357 mag, .44 magnum, .45 Colt. They'd sell I tell ya.