M&P definitely, especially for the cost it's as good a gun as the USP. For the record, I've owned both and sold both. I love the Glock (in 9mm) but I wouldn't get it in .45.
Cost aside I believe it to be a much more shootable handgun. The USP .45 shoots like a brick and is noticeably bigger. USP Muzzle-flip is much more significant though felt recoil is less than the M&P. That said, the USP is built like a tank, but imo it's overengineered...like most things in Germany.
The reason I got rid of the M&P had nothing to do with any flaws in the gun, but rather because I am simplifying my collection: Glock in 9mm and 1911 in .45.
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