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Thread: Got Testosterone?

  1. #921
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    Quote Originally Posted by Hmac View Post
    Inguinal hernia in rats is not a thing.
    Rgr rgr. From how you said it, thought you meant in humans. I'm not a rat anatomist but it appears the equivalent is a Scrotal Hernia if I read correctly. A potentially interesting area of investigation that merits follow up. An interesting write up with more background. Apparently, as with so many discoveries, found during a different investigation:

    http://www.news-medical.net/news/201...older-men.aspx

    Source study:

    https://plan.core-apps.com/tristar_e...a03154444733b4
    Last edited by WillBrink; 04-23-17 at 09:41.
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  2. #922
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    No, I'm very clear on the extent and impact of inguinal hernia in older males. I diagnose them and fix them at least a couple of times a week.

    Scrotal hernia and indirect inguinal hernia are the same thing.

  3. #923
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    Quote Originally Posted by Hmac View Post
    No, I'm very clear on the extent and impact of inguinal hernia in older males. I diagnose them and fix them at least a couple of times a week.

    Scrotal hernia and indirect inguinal hernia are the same thing.
    Thanx for clarification. Apparently rats can suffer a Scrotal hernia. Whether causes/mechanisms in rats are human equivalent needs to be studied further no doubt.
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  4. #924
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    Quote Originally Posted by WillBrink View Post
    Thanx for clarification. Apparently rats can suffer a Scrotal hernia. Whether causes/mechanisms in rats are human equivalent needs to be studied further no doubt.
    The anatomy is similar. Scrotal/indirect inguinal hernia in humans is the same thing as scrotal/indirect inguinal hernia in rats. Scrotal hernia is just a more extensive version of indirect inguinal hernia. The difference is that it's hard to get a rat to turn its head and cough, consequently it's only diagnosed when it's clinically advanced that far with a visible bulge. In humans, they complain of pain earlier so it's diagnosed earlier.

  5. #925
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    Quote Originally Posted by Hmac View Post
    The anatomy is similar. Scrotal/indirect inguinal hernia in humans is the same thing as scrotal/indirect inguinal hernia in rats. Scrotal hernia is just a more extensive version of indirect inguinal hernia. The difference is that it's hard to get a rat to turn its head and cough, consequently it's only diagnosed when it's clinically advanced that far with a visible bulge. In humans, they complain of pain earlier so it's diagnosed earlier.
    Supported by the researchers experience:

    " One day the investigators noticed that the male mice, used for breeding, could not walk and had a swollen lower abdomen. They initially thought the swelling was a tumor but later realized it was an extremely large groin hernia."
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  6. #926
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    An interesting and unexpected finding about T. Will an asmtha attack be treated with a shot of T in the future? More data needed for sure:


    Science News

    Testosterone explains why women more prone to asthma

    Summary:

    An international research team has revealed for the first time that testosterone protects males against developing asthma, helping to explain why females are two times more likely to develop asthma than males after puberty. The study showed that testosterone suppresses the production of a type of immune cell that triggers allergic asthma. The finding may lead to new, more targeted asthma treatments.

    Cont:

    https://www.sciencedaily.com/release...0508112433.htm

    Source:

    Sophie Laffont, Eve Blanquart, Magali Savignac, Claire Cénac, Gilles Laverny, Daniel Metzger, Jean-Philippe Girard, Gabrielle T. Belz, Lucette Pelletier, Cyril Seillet, Jean-Charles Guéry. Androgen signaling negatively controls group 2 innate lymphoid cells. The Journal of Experimental Medicine, 2017; jem.20161807
    Last edited by WillBrink; 05-08-17 at 14:52.
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  7. #927
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    More reasons docs need to stop relying on total T as the only metric of hormonal status and why competent TRT/HRT docs will look at and adjust am array of hormones knowing it's essential to getting the best effects for the people with work with:

    AUA 2017: Calculated Free T and T:E Ratio but not Total Testosterone and Estradiol Predict Low Libido

    Boston, MA (UroToday.com) Libido is thought to be influenced by hormonal milieu, particularly testosterone. The knowledge about the role of estradiol in male sexual function has been found to be more important than originally thought. The estradiol cut-off point of 5 ng/dL in hypogonadal men is thought to directly affect libido. Dr. Gupta presented a study assessing the impact of sex hormones on libido specifically in a cardiac patient population.

    Cont:

    https://www.urotoday.com/conference-...ow-libido.html
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  8. #928
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    Large studies coming out suggesting TRT is protective:

    Testosterone Replacement Therapy May Protect Against Stroke, Heart Attack in Hypogonadism

    Testosterone replacement therapy (TRT) may exhibit a protective effect against myocardial infarction, stroke, and all-cause mortality in men with secondary hypogonadism. The findings were presented at the 26th Annual Scientific and Clinical Congress of the American Association for Clinical Endocrinologists (AACE), held May 3-7, 2017, in Austin, Texas.

    Given that there has been growing concern that TRT may be associated with an increased risk for adverse cardiovascular outcomes or mortality, investigators led by Joyce George, MD, of the Cleveland Clinic in Ohio, conducted a retrospective cohort study using electronic health records from a large health care database to examine outcomes.

    Records for men at least 40 years of age, with at least 2 testosterone levels <220 ng/dL (one obtained between 7 am and 10 am) were pulled from the database. Patients with primary hypogonadism, secondary hypogonadism related to overt hypothalamic pituitary pathology, HIV infection, metastatic cancer, a history of prostate cancer, prostate specific antigen >4 ng/mL, elevated hematocrit, or a history of previous thromboembolic disease were not included in the final cohort.

    The study ultimately included 418 men (median age 53.8 years) exposed to TRT and 283 matched controls (median age 54.9 years; P =.02). At baseline, the prevalence of established cardiovascular disease was 9.8% vs 12.7%, respectively (P =.23). The treatment group was followed for a median of 3.8 years compared with 3.4 years for the control group.

    The event composite outcome in the treatment group was 3.3% compared with 6.4% in the control group, with the investigators ultimately observing a reduction in the odds of the combined cardiovascular end point in the treatment group (hazard ratio [HR] 0.49; 95% CI, 0.24-0.99; P =.046).

    While “the effect of TRT may vary considerably depending on the etiology of low testosterone, the patient's age, and whether or not they have established CV [cardiovascular] disease,” the results suggest TRT may protect some men with hypogonadism from cardiovascular events, the investigators concluded.

    Cont:

    http://www.endocrinologyadvisor.com/...rticle/654941/
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  9. #929
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    This thread has been life changing for me.

    I just came across this website and the video is fresking outstanding! I will probably watch it a few more times. I'd like to get my local doc to watch it too.

    DOSAGES FOR MEN

    50mg Testosterone enanthate/cypionate injections every third day.

    0.25mg Arimidex every third day.

    500IU HCG every third day.

    https://youtu.be/k7eu9RnZOvI

    https://www.menshormonalhealth.com/t...e-therapy.html
    "Real men have always needed to know what time it is so they are at the airfield on time, pumping rounds into savages at the right time, etc. Being able to see such in the dark while light weights were comfy in bed without using a light required luminous material." -Originally Posted by ramairthree

  10. #930
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    Quote Originally Posted by usmcvet View Post
    This thread has been life changing for me.

    I just came across this website and the video is fresking outstanding! I will probably watch it a few more times. I'd like to get my local doc to watch it too.

    DOSAGES FOR MEN

    50mg Testosterone enanthate/cypionate injections every third day.

    0.25mg Arimidex every third day.

    500IU HCG every third day.
    Few thoughts here. Smaller doses of T more often is the in thing these days, some doing very small doses (20mg) daily. Some feel better on such schedules, but frankly it shows a lack of understanding of the pharmacokinetics of those esters. Use of Arimidex without showing a need for it (via blood work showing elevated E2) is a waste of $ and can cause side effects, lower HDL, etc. Docs adding in Arimidex as part of standard protocol without doing so to address elevated E2 (as not all men experience elevated E2), are using bad medicine. Three, that dose of HCG higher than needed to maintain fertility and gonadal function and may lead to elevated E2.

    Those who want to take their knowledge base on this topic, including docs you may be working with, should join the excelmale site and forums. I'd be happy to speak with your doc if needed.
    - Will

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