The glock striker is not mounted until you pull the trigger, and it has a FP safety. If you protect the trigger from being pulled, it won't shoot.
Some other modern pistols may drop the hammer due to a heavy blow (specially if they have tuned sears/hammer hooks), but most have a firing pin safety that will prevent firing.
Now, if you have a pistol with sears/hammer hooks tuned for a light release, and it does not have a FP safety, all that is preventing an accidental shot in a situation like this is the hammer safety notch, and this is not a very positive safety.
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