Anything that liquiefies the heart/major vascular structures is effective. No dissent. Issues arise with non fully-frontal shots. If the only shot you have is through the bicep/shoulder, then the bullet must penetrate the shoulder, humerous, more muscle of the arm, fat and muscle around the rib-cage, the ribcage, the lung, and significant portions of the heart/major vascular structures. This is where the requirement for a minimum of 12" of penetration comes from.
A ballistic tip
may cause more damage to a limb than other types, but it may not. Even the robust M-47 AK round can cause massive damage to limbs despite their non-fragmentary performance (
see this link). Either way, damage to limbs cannot be relied upon as a stopper. Even significant blood loss from a severed brachial artery may take hours to cause incapacitation (Hemorrhagic Shock).
Gunshots themselves are not instantly painful or unbalancing enough, especially when the victim is under the influence of alcohol, drugs, or adrenaline, to promise incapacitation. Though most non-CNS single shot incapacitations are psychological, the phenominon is not reliable as a method of stopping.
This is true, multiple shots are better, but is outside the scope of the discussion, and is heavly dependant on the method of employment. One shot is all you might get.
If we are talking about use inside a residence, the average shot distance will be measured in feet, not yards. Consider that an average man can cover 7 yards (21 feet) in 1.5 seconds. If that man begins closing with you, as you make the decision to fire, you just lost about .2-.3 seconds to identify, decide, and act. Sweeping the safety and raising the muzzle will take you another .1-.2 seconds. Establishing some kind of sight picture will take another .1-.3 seconds. This leaves you with 1.1 to .7 seconds (with times that are assuming a high degree of proficiency with no performance degredation under stress) before the aggressor will be physically occupying the space you are, during which time you say you are going to assess the shot's effectiveness.
Since the muzzle of a 16" carbine is about 2'-3' from your actual position, the BG will be inside the muzzle in even less than 1.5 seconds. Now just imagine you are actually at room distances, which will be about 10'.
The times needed are not just to get off a shot, but to incapacitate the threat.
The shot after the assessment may be 5 pounds away, but it will be about 1/2 second too late.
Of course, the same argument could be used for any type of round, but shots that penetrate the heart have a much higher incidence of rapid incapacitation than any other non-CNS shot. Either way, count on shooting until the threat drops.
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