Vite D and Weight Loss

[WillBrink]

Take home of this study: those getting the vitamin D supplementation who became replete [blood levels increased to 25(OH)D to 32 ng/mL or above] lost more weight and had greater improvements in body composition compared with women who did not.

Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial.

Am J Clin Nutr. 2014 May;99(5):1015-25. doi: 10.3945/ajcn.113.073734. Epub 2014 Mar 12.


Abstract

BACKGROUND:

Vitamin D deficiency is associated with obesity; whether repletion supports weight loss and changes obesity-related biomarkers is unknown.
OBJECTIVE:

We compared 12 mo of vitamin D3 supplementation with placebo on weight, body composition, insulin, and C-reactive protein (CRP) in postmenopausal women in a weight-loss intervention.

DESIGN:

A total of 218 overweight/obese women (50-75 y of age) with serum 25-hydroxyvitamin D [25(OH)D] ≥10 ng/mL but <32 ng/mL were randomly assigned to weight loss + 2000 IU oral vitamin D3/d or weight loss + daily placebo. The weight-loss intervention included a reduced-calorie diet (10% weight loss goal) and 225 min/wk of moderate-to-vigorous aerobic activity. Mean 12-mo changes in weight, body composition, serum insulin, CRP, and 25(OH)D were compared between groups (intent-to-treat) by using generalized estimating equations.

RESULTS:

A total of 86% of participants completed the 12-mo measurements. The mean (95% CI) change in 25(OH)D was 13.6 (11.6, 15.4) ng/mL in the vitamin D3 arm compared with -1.3 (-2.6, -0.3) ng/mL in the placebo arm (P < 0.0001). Changes in weight [-7.1 (-8.7, -5.7) compared with -7.4 (-8.1, -5.4) kg], body mass index (in kg/m(2): both -2.8), waist circumference [-4.9 (-6.7, -2.9) compared with -4.5 (-5.6, -2.6) cm], percentage body fat [-4.1 (-4.9, -2.9) compared with -3.5 (-4.5, -2.5)], trunk fat [-4.1 (-4.7, -3.0) compared with -3.7 (-4.3, -2.9) kg], insulin [-2.5 (-3.4, -1.7) compared with -2.4 (-3.3, -1.4) μU/mL], and CRP [-0.9 (-1.2, -0.6) compared with -0.79 (-0.9, -0.4) mg/L] [corrected] were similar between groups (all P > 0.05). Compared with women who achieved 25(OH)D <32 ng/mL, women randomly assigned to vitamin D who became replete (ie, 25(OH)D ≥32 ng/mL) lost more weight [-8.8 (-11.1, -6.9) compared with -5.6 (-7.2, -5.0) kg; P = 0.05], waist circumference [-6.6 (-9.3, -4.3) compared with -2.5 (-4.6, -2.0) cm; P = 0.02], and percentage body fat [-4.7 (-6.1, -3.5) compared with -2.6 (-3.9, -2.2); P = 0.04]. Among women with complete pill counts (97% adherence), the mean decrease in CRP was 1.18 mg/mL (46%) in the vitamin D arm compared with 0.46 mg/mL (25%) in the placebo arm (P = 0.03).

CONCLUSIONS:

Vitamin D3 supplementation during weight loss did not increase weight loss or associated factors compared with placebo; however, women who became replete experienced greater improvements. This trial was registered at clinicaltrials.gov as NCT01240213.

http://www.ncbi.nlm.nih.gov/pubmed/24622804

[skijunkie55]

Lack of sunlight (vitamin D) makes you depressed. Depression makes you eat more. Eating more makes you fat. Solid science.

http://psychcentral.com/lib/10-thing...-disorder/0002

Maybe not related, but in Michigan we get a lot of chubby moody gals in the winter time

[WillBrink]

Lack of sunlight (vitamin D) makes you depressed. Depression makes you eat more. Eating more makes you fat. Solid science.

http://psychcentral.com/lib/10-thing...-disorder/0002

Maybe not related, but in Michigan we get a lot of chubby moody gals in the winter time

Works for me! Here's excellent intel on all that:

Vitamin D – what’s the optimal level and how to achieve it?

[CLHC]

Here's more information from Fred Hutchinson Cancer Research Center in Seattle.

https://www.fredhutch.org/en/news/re...ight-loss.html

http://www.fredhutch.org/en/labs/phs...-overview.html

At work, Cholecalciferol is prescribed and dispensed regularly. That is a fast mover off our shelves.

[Vic303]

I supp D3 10k IU daily. My doc is happy with my D levels at 63 Ng/ml.

[WillBrink]

I supp D3 10k IU daily. My doc is happy with my D levels at 63 Ng/ml.

And it took 10k IU to get it there! Doses needed to get 25OD levels into that range varies widely between people I find, so testing is essential for optimizing dose.

[Vic303]

And it took 10k IU to get it there! Doses needed to get 25OD levels into that range varies widely between people I find, so testing is essential for optimizing dose.

The test is one of my annual or semi annual labs run, and fortunately for me, the supps are a simple way for me to get my numbers up and keep them there.

[WillBrink]

The test is one of my annual or semi annual labs run, and fortunately for me, the supps are a simple way for me to get my numbers up and keep them there.

5IU seems about right for most people most of the time, but I know some where 1k IU will do it. and many more who need at least 10KIU +.