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Thread: Psilocybin Mushrooms and depression

  1. #11
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    Another study of interest:

    Eating magic mushrooms can treat depression, study finds

    The drug 'resets' the brain circuits to immediately improve moods

    Eating magic mushrooms can help treat depression.

    That's according to a new study that found that the drug psilocybin, found in mushrooms, can "reset" the brain's circuits and help ease symptoms.

    Scientists got special permission to give the mushrooms to 19 people who had not been helped by traditional treatments. They said their mood was lifted immediately, and that in some cases the effect would last as long as five weeks.

    Brain scans showed that the neural circuits in the brain had been reset, pushing them out of their depressive states, the scientists found.

    Cont:

    https://www.independent.co.uk/news/s...-a7998166.html
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  2. #12
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    Tad OT, but still though this the best place for it. Gets the award for the coolest hypothesis of how we split off from our cousins to develop the big brains:

    "Imagine Homo erectus, a now-extinct species of hominids that stood upright and became the first of our ancestors to move beyond a single continent. Around two million years ago, these hominids, some of whom eventually evolved into Homo sapiens, began to expand their range beyond Africa, moving into Asia and Europe. Along the way, they tracked animals, encountered dung, and discovered new plants.

    But that’s just the version of our origin story that happens to be widely accepted by scientists.

    A more radical interpretation of these events involves the same animals, dung, and plants but also includes psychedelic drugs. In 1992, ethnobotanist and psychedelics advocate Terence McKenna argued in the book Food of the Gods that what enabled Homo erectus to evolve into Homo sapiens was its encounter with magic mushrooms and psilocybin, the psychedelic compound within them, on that evolutionary journey. He called this the Stoned Ape Hypothesis.

    McKenna posited that psilocybin caused the primitive brain’s information-processing capabilities to rapidly reorganize, which in turn kick-started the rapid evolution of cognition that led to the early art, language, and technology written in Homo sapiens’ archeological record. As early humans, he said we “ate our way to higher consciousness” by consuming these mushrooms"

    Cont:

    https://www.inverse.com/article/3418...ape-hypothesis
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  3. #13
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    Cool hypothesis indeed. However, both Terence and Dennis McKenna are loony toons IMO. Despite my opinions of the two, I still think Psilocybin has great potential in many areas - neurogenesis and psychiatry being all but two of them.

    There is a recent "interview" between Joe Rogan and Paul Stamets, a world renowned mycologist, that you will likely find interesting. They even mention the McKennas.

    https://youtu.be/mPqWstVnRjQ




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  4. #14
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    The same is being said about LSD. As with all studies I question who paid for the study? The SSRIs seem not to be as good as the people that push them say they are.
    Last edited by SteveS; 11-26-17 at 11:56.

  5. #15
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    Quote Originally Posted by scooter22 View Post
    Cool hypothesis indeed. However, both Terence and Dennis McKenna are loony toons IMO. Despite my opinions of the two, I still think Psilocybin has great potential in many areas - neurogenesis and psychiatry being all but two of them.

    There is a recent "interview" between Joe Rogan and Paul Stamets, a world renowned mycologist, that you will likely find interesting. They even mention the McKennas.

    https://youtu.be/mPqWstVnRjQ
    One can be a loon, but still brilliant loon with plenty to contribute. I can't say if that's the case for those gents as the topic is out of my lane to say one way or another, but being a loon does not defacto negate the intel per se. Known some real interesting loons in my day
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  6. #16
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    All I know is the 10 or so times I've done mushrooms in my early and mid twenty's I had tons of fun

  7. #17
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    Study on mushrooms and depression with measured with functional magnetic resonance imaging (fMRI).

    Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

    Scientific Reports volume 7, Article number: 13187 (2017)

    Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD).

    Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF correlated with reduced depressive symptoms. Focusing on a priori selected circuitry for RSFC analyses, increased RSFC was observed within the default-mode network (DMN) post-treatment. Increased ventromedial prefrontal cortex-bilateral inferior lateral parietal cortex RSFC was predictive of treatment response at 5-weeks, as was decreased parahippocampal-prefrontal cortex RSFC.

    These data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients. The post-treatment brain changes are different to previously observed acute effects of psilocybin and other ‘psychedelics’ yet were related to clinical outcomes. A ‘reset’ therapeutic mechanism is proposed.

    https://www.nature.com/articles/s41598-017-13282-7
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  8. #18
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    You can go to YouTube and listen to Dorian Yates experience with psychoactive drugs treating his depression.
    Interesting interview and a very interesting guy.

  9. #19
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    Quote Originally Posted by Averageman View Post
    You can go to YouTube and listen to Dorian Yates experience with psychoactive drugs treating his depression.
    Interesting interview and a very interesting guy.
    I have known Dorian for a long time and discussed that one.
    - Will

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    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  10. #20
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    I only recently found those videos.
    Very impressive information about a very impressive guy.
    It would appear he set a goal, educated himself and then became the best in the world in a very competitive sport.
    Pretty Amazing.

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