Quote Originally Posted by Hmac View Post
In my mind, that paper is suspect. Previous studies have not indicated similar results. Additionally, they depend on tracking prescriptions and even then can't get an accurate handle on dosage, and finally, they had no way of accounting for OTC ibuprofen.
such Epi studies are what they are of course and cause and effect can't be determined from them. Here's a review. It's a tad dated (2010) but extensive. Might be something more recent:

Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036661/

Interestingly, those with pre existing pain and inflammation, NSID's may be protective for CV events, but I have not read the full paper:

https://www.ncbi.nlm.nih.gov/pubmed/27575590

Seems jury still out on some NSIDs and CV risks, but evidence does seem to be mounting and as you know, other risks exist when using long term.