Covid 19: adjuvant approaches etc,

**WillBrink** · 09-25-21, 14:04

Folks, J. of Oxidative Medicine and Cellular Longevity has put out a special issue “Oxidative Stress in the Pathogenesis of COVID-19” (1)

Below is an example of a paper, which further supports my original premise (2) and direct intervention studies with GSH and or GSH precursors is required and needed badly:

Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019

Objective. Aminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated.

Methods. The total content () and reduced forms () of aminothiols were determined in patients with COVID-19 () on admission. Lung injury was characterized by computed tomography (CT) findings in accordance with the CT0-4 classification.

Results. Low tGSH level was associated with the risk of severe COVID-19 (, mild vs. moderate/severe: , ) and degree of lung damage (, vs. : , ). The rGSH level showed a negative association with D-dimer levels (, ). Low rCG level was also associated with the risk of lung damage (, vs. : , ). Levels of rCG (, ) and especially tCG (, ) were negatively associated with platelet count. In addition, a significant relationship was found between the advanced oxidation protein product level and tGSH in patients with moderate or severe but not in patients with mild COVID-19.

Conclusion. Thus, tGSH and rCG can be seen as potential markers for the risk of severe COVID-19. GSH appears to be an important factor to oxidative damage prevention as infection progresses. This suggests the potential clinical efficacy of correcting glutathione metabolism as an adjunct therapy for COVID-19

Full paper: https://www.hindawi.com/journals/omcl/2021/9221693/

(1) https://www.hindawi.com/journals/omcl/si/893058/

(2) https://brinkzone.com/life-saving-st...complications/

**WillBrink** · 09-25-21, 14:20

And another...

https://www.hindawi.com/journals/omcl/2021/8671713/

**WillBrink** · 09-28-21, 15:09

Gents, meta of possible interest, still in review:

COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis

Abstract
Background Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.

Methods Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex and diabetes. Data were analyzed using correlation and linear regression.
Results One population study and seven clinical studies were identified, which reported D3 blood levels pre-infection or on the day of hospital admission. They independently showed a negative Pearson correlation of D3 levels and mortality risk (r(17)=-.4154, p=.0770/r(13)=-.4886, p=.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/ml (17.4 – 26.8), and a significant Pearson correlation was observed (r(32)=-.3989, p=.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/ml D3.

Conclusions The two datasets provide strong evidence that low D3 is a predictor rather than a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/ml to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.

https://www.medrxiv.org/content/10.1...1263977v1.full

**everready73** · 09-29-21, 08:05

Originally Posted by WillBrink

Gents, meta of possible interest, still in review:

COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis

Abstract
Background Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.

Methods Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex and diabetes. Data were analyzed using correlation and linear regression.
Results One population study and seven clinical studies were identified, which reported D3 blood levels pre-infection or on the day of hospital admission. They independently showed a negative Pearson correlation of D3 levels and mortality risk (r(17)=-.4154, p=.0770/r(13)=-.4886, p=.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/ml (17.4 – 26.8), and a significant Pearson correlation was observed (r(32)=-.3989, p=.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/ml D3.

Conclusions The two datasets provide strong evidence that low D3 is a predictor rather than a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/ml to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.

I have some routine blood work scheduled soon and am going to have them check my D levels as well

https://www.medrxiv.org/content/10.1...1263977v1.full

Good info Will. I started taking 5000IU of D3 when original data came out last year. showing it may be effective. I think one of the studies said that 94% of people in ICU for covid were vit d deficient (don't quote me on exact numbers, but it was significant). This further proves how important it is to combat COVID

**tgizzard** · 09-29-21, 19:08

Originally Posted by WillBrink

Gents, meta of possible interest, still in review:

COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis

Abstract
Background Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.

Methods Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex and diabetes. Data were analyzed using correlation and linear regression.
Results One population study and seven clinical studies were identified, which reported D3 blood levels pre-infection or on the day of hospital admission. They independently showed a negative Pearson correlation of D3 levels and mortality risk (r(17)=-.4154, p=.0770/r(13)=-.4886, p=.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/ml (17.4 – 26.8), and a significant Pearson correlation was observed (r(32)=-.3989, p=.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/ml D3.

Conclusions The two datasets provide strong evidence that low D3 is a predictor rather than a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/ml to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.

https://www.medrxiv.org/content/10.1...1263977v1.full

Thank you for posting. I've been supplementing with D3, Zinc, and Vitamin C since reading these could reduce one's reaction to Covid.

**Inkslinger** · 09-29-21, 19:20

Originally Posted by tgizzard

Thank you for posting. I've been supplementing with D3, Zinc, and Vitamin C since reading these could reduce one's reaction to Covid.

If you get the zinc with quercetin it’s supposed to make the zinc more bio available.

**WillBrink** · 10-15-21, 13:19

All, an RCT with arginine and covid via The Lancet. I hadn’t really considered arginine for potential benefit in covid treatment, but if the mechanism is via NO and improved endothelial function, it makes some sense. I was also surprised how low the dose was for the outcomes found:

Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis

Abstract
Background
We and others have previously demonstrated that the endothelium is a primary target of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and L-arginine has been shown to improve endothelial dysfunction. However, the effects of L-arginine have never been evaluated in coronavirus disease 2019 (COVID-19).

Methods
This is a parallel-group, double-blind, randomized, placebo-controlled trial conducted on patients hospitalized for severe COVID-19. Patients received 1.66 g L-arginine twice a day or placebo, administered orally. The primary efficacy endpoint was a reduction in respiratory support assessed 10 and 20 days after randomization. Secondary outcomes were the length of in-hospital stay, the time to normalization of lymphocyte number, and the time to obtain a negative real-time reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 on nasopharyngeal swab.

Findings
We present here the results of the initial interim analysis on the first 101 patients. No treatment-emergent serious adverse events were attributable to L-arginine. At 10-day evaluation, 71.1% of patients in the L-arginine arm and 44.4% in the placebo arm (p < 0.01) had the respiratory support reduced; however, a significant difference was not detected 20 days after randomization. Strikingly, patients treated with L-arginine exhibited a significantly reduced in-hospital stay vs placebo, with a median (interquartile range 25th,75th percentile) of 46 days (45,46) in the placebo group vs 25 days (21,26) in the L-arginine group (p < 0.0001); these findings were also confirmed after adjusting for potential confounders including age, duration of symptoms, comorbidities, D-dimer, as well as antiviral and anticoagulant treatments. The other secondary outcomes were not significantly different between groups.

Interpretation
In this interim analysis, adding oral L-arginine to standard therapy in patients with severe COVID-19 significantly decreases the length of hospitalization and reduces the respiratory support at 10 but not at 20 days after starting the treatment.

https://www.thelancet.com/journals/e...405-3/fulltext

**ride57** · 10-18-21, 18:21

Here is a book I am leafing through. It is interesting if you are into Chinese medicine. It is free on Kindle.

Use Of Patented Traditional Chinese Medicine Against Covid-19: A Practical Manual .

https://www.amazon.com/Patented-Trad...4599189&sr=8-1