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Thread: Covid 19: adjuvant approaches etc,

  1. #101
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    Folks, J. of Oxidative Medicine and Cellular Longevity has put out a special issue “Oxidative Stress in the Pathogenesis of COVID-19” (1)

    Below is an example of a paper, which further supports my original premise (2) and direct intervention studies with GSH and or GSH precursors is required and needed badly:

    Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019

    Objective. Aminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated.

    Methods. The total content () and reduced forms () of aminothiols were determined in patients with COVID-19 () on admission. Lung injury was characterized by computed tomography (CT) findings in accordance with the CT0-4 classification.

    Results. Low tGSH level was associated with the risk of severe COVID-19 (, mild vs. moderate/severe: , ) and degree of lung damage (, vs. : , ). The rGSH level showed a negative association with D-dimer levels (, ). Low rCG level was also associated with the risk of lung damage (, vs. : , ). Levels of rCG (, ) and especially tCG (, ) were negatively associated with platelet count. In addition, a significant relationship was found between the advanced oxidation protein product level and tGSH in patients with moderate or severe but not in patients with mild COVID-19.

    Conclusion. Thus, tGSH and rCG can be seen as potential markers for the risk of severe COVID-19. GSH appears to be an important factor to oxidative damage prevention as infection progresses. This suggests the potential clinical efficacy of correcting glutathione metabolism as an adjunct therapy for COVID-19

    Full paper: https://www.hindawi.com/journals/omcl/2021/9221693/

    (1) https://www.hindawi.com/journals/omcl/si/893058/

    (2) https://brinkzone.com/life-saving-st...complications/
    Last edited by WillBrink; 09-25-21 at 14:21.
    - Will

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    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  2. #102
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    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  3. #103
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    Gents, meta of possible interest, still in review:

    COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: Results of a systematic review and meta-analysis

    Abstract
    Background Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.

    Methods Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex and diabetes. Data were analyzed using correlation and linear regression.
    Results One population study and seven clinical studies were identified, which reported D3 blood levels pre-infection or on the day of hospital admission. They independently showed a negative Pearson correlation of D3 levels and mortality risk (r(17)=-.4154, p=.0770/r(13)=-.4886, p=.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/ml (17.4 – 26.8), and a significant Pearson correlation was observed (r(32)=-.3989, p=.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/ml D3.

    Conclusions The two datasets provide strong evidence that low D3 is a predictor rather than a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/ml to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.

    https://www.medrxiv.org/content/10.1...1263977v1.full
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

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