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Thread: Covid 19: adjuvant approaches etc,

  1. #121
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    Quote Originally Posted by WillBrink View Post
    Study of interest:

    WEST LAFAYETTE, Ind. — Scientists recently gained insights into how vitamin D functions to reduce inflammation caused by immune cells that might be relevant to the responses during severe COVID-19. In a study jointly published by Purdue University and the National Institutes of Health, scientists do just that.

    https://www.purdue.edu/newsroom/rele...lammation.html

    Study:

    Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
    Nature Immunology (2021)

    Abstract

    The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1 helper T (TH1) cell responses remain poorly understood. Here we show that complement triggers contraction of TH1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor and the VitD-activating enzyme CYP27B1, permitting T cells to both activate and respond to VitD. VitD then initiated the transition from pro-inflammatory interferon-γ+ TH1 cells to suppressive interleukin-10+ cells. This process was primed by dynamic changes in the epigenetic landscape of CD4+ T cells, generating super-enhancers and recruiting several transcription factors, notably c-JUN, STAT3 and BACH2, which together with VitD receptor shaped the transcriptional response to VitD. Accordingly, VitD did not induce interleukin-10 expression in cells with dysfunctional BACH2 or STAT3. Bronchoalveolar lavage fluid CD4+ T cells of patients with COVID-19 were TH1-skewed and showed de-repression of genes downregulated by VitD, from either lack of substrate (VitD deficiency) and/or abnormal regulation of this system.

    https://www.nature.com/articles/s41590-021-01080-3
    So the first link says it's not the Vitamin D supplements

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  2. #122
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    Quote Originally Posted by Arik View Post
    So the first link says it's not the Vitamin D supplements

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    It's a downstream metabolite of D3, and if you read between the lines of their irrational fear of taking high dose D (which data does not support BTW...) for covid, explains that, and abstracts below more so.

    Would ingestion of the active metabolite be more effective and or efficient? Very possible, but needs data and far as I know, not avialiable yet, so D3 supps are the current option, and that metabolite may explain some of the anti inflammatory benefits of D3, specfucu to covid.

    FYI, It's essential to get adequate Mg for production of active metabolites of D3:

    https://brinkzone.com/is-magnesium-t...-to-the-big-d/
    Last edited by WillBrink; 11-22-21 at 16:39.
    - Will

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    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  3. #123
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    I was diagnosed with low vitamin D a few years before COVID. Maybe 2016 - 17 or so. It was like 13ng/mL. Since then I've been talking supplements and they've varied been 500IU to 2000IU. My last blood work in June showed 45.6 ng/mL

    Since new year I've been cranking it up to 8-10k IU but I started noticing what I think are side effects so lately I've gone down to 6000IU and will occasionally skip a day. Seems to be working and the side effects are less and less frequent.

    I do eat everything with the exception of carbs. Every day meat, (whole) vegetables and (whole) fruits but I've never tested for magnesium

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  4. #124
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    Quote Originally Posted by Arik View Post
    Since new year I've been cranking it up to 8-10k IU but I started noticing what I think are side effects so lately I've gone down to 6000IU and will occasionally skip a day.
    If it is not too private what were those possible side effects?

  5. #125
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    Quote Originally Posted by Disciple View Post
    If it is not too private what were those possible side effects?
    I started getting occasional heart palpitations. Which became almost daily which became multiple times per day. Not all the time, not every day but very very often. To the point that if I didn't have one a day I'd notice. Never lasting more than a split second. Happened to look it up and one of the side effects of too much vitamin D is heart palpitations. I stopped taking them for a few weeks just to see and the symptoms decreased to the point of almost going away. I started taking 4k IU then 6k now with just a rare occurrence that's becoming less intense and more rare

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    Last edited by Arik; 11-22-21 at 17:29.

  6. #126
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    Quote Originally Posted by Arik View Post
    I started getting occasional heart palpitations. Which became almost daily which became multiple times per day. Not all the time, not every day but very very often. To the point that if I didn't have one a day I'd notice. Never lasting more than a split second. Happened to look it up and one of the side effects of too much vitamin D is heart palpitations. I stopped taking them for a few weeks just to see and the symptoms decreased to the point of almost going away. I started taking 4k IU then 6k now with just a rare occurrence that's becoming less intense and more rare

    Sent from my moto z4 using Tapatalk
    May be due to increased rec for Mag, so adding in some Mg and getting 25OHD levels checked again would be warranted. I find for most, 5k IU seems to be the dose that gets the optimal levels.
    - Will

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  7. #127
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    How much would be good without overdoing it? 300mg/day + food? Less?

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  8. #128
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    Quote Originally Posted by Arik View Post
    How much would be good without overdoing it? 300mg/day + food? Less?

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    That's a good number to shoot for.
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

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