Page 3 of 3 FirstFirst 123
Results 21 to 27 of 27

Thread: Covid 19: adjuvant approaches etc,

  1. #21
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    15,348
    Feedback Score
    5 (100%)
    Not A study, but very much in line with recs and suggestive data already posted. I think this a win for covid patients.

    New York hospitals treating coronavirus patients with vitamin C

    The regimen is based on experimental treatments administered to people with the coronavirus in Shanghai, China, Weber said.

    “The patients who received vitamin C did significantly better than those who did not get vitamin C,” he said.

    “It helps a tremendous amount, but it is not highlighted because it’s not a sexy drug.”

    A spokesman for Northwell — which operates 23 hospitals, including Lenox Hill Hospital on Manhattan’s Upper East Side — said vitamin C was being “widely used” as a coronavirus treatment throughout the system, but noted that medication protocols varied from patient to patient.

    “As the clinician decides,” spokesman Jason Molinet said.

    About 700 patients are being treated for coronavirus across the hospital network, Molinet said, but it’s unclear how many are getting the vitamin C treatment.

    Cont:

    https://nypost.com/2020/03/24/new-yo...ith-vitamin-c/
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  2. #22
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    15,348
    Feedback Score
    5 (100%)
    This one is more an FYI. I tend to think the hyper immune aspect of Covid can be mitigated via various existing approaches discussed in this thread, but it will be interesting to see how this turns out:

    Gents, and interesting development that may be of interest happening in FL:

    ‘Amazing potential.’ UM doctor to start stem cell trial for coronavirus patients

    A team of doctors at the University of Miami won emergency federal approval to use stem cell therapy on patients suffering severe lung inflammation from COVID-19. The treatment will begin this week, starting with a dozen patients.

    The UM Miller School of Medicine doctors are proposing to block the inflammation using an intravenous infusion of stem cells from umbilical cords, building on promising but limited results from a 10-patient study in China. The Food and Drug Administration granted immediate authorization for the trial earlier this week.

    Dr. Camillo Ricordi, a UM professor and stem cell therapy researcher, said the cells derived from one umbilical cord, which are typically discarded after a woman gives birth, could generate enough stem cells to treat over 10,000 patients. Stem cells have the capability of becoming specialized cells that sometimes repair damage, and the type taken from umbilical cords — known as mesenchymal stem cells — are adaptable to a number of uses.

    Cont:

    https://www.miamiherald.com/news/hea...242008576.html
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  3. #23
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    15,348
    Feedback Score
    5 (100%)
    And speaking of stem cells, there is something seemingly worth pursuing as apparently early results looked very promising and follow up study will happen:

    "The stem cells were produced by RESTEM, a leading-edge biotechnology company dedicated to the discovery and development of cell-based therapeutics. RESTEM’s cells are grown from umbilical cord tissue by a proprietary process and reduce inflammation, thereby allowing tissue regeneration and healing to occur.

    The patients who received the treatment were on ventilation support and showed reduction of their oxygen requirement from 100 percent to less than 50 percent within days of the infusion. This was accompanied by a significant reduction in levels of various key circulating inflammatory markers, meaning the harmful inflammation crippling the lungs of all three patients was not only arrested but reversed.

    “The remarkable ability for these cells to mitigate inflammatory processes holds great promise for COVID-19 patients as well as for people with many other illnesses,” said Dr. Koehne, deputy director and chief of blood & marrow transplant at Miami Cancer Institute, part of Baptist Health, and Principal Investigator for the study, which is currently undergoing review at the FDA. “These patients have improved their lung status much more quickly than patients treated with other experimental therapies.”

    Cont:

    https://baptisthealth.net/baptist-he...aptist-health/
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  4. #24
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    15,348
    Feedback Score
    5 (100%)
    As some of you are aware, they're seeing a Kawasaki like response in children exposed to Covid and it's been fatal in some.

    And what gets the hyper inflammation ball rolling during the acute phase? Oxidative stress apparantly:

    Oxidative stress and Kawasaki disease: how is oxidative stress involved from the acute stage to the chronic stage?

    Rheumatology (Oxford). 2017 Jan;56(1):6-13. doi: 10.1093/rheumatology/kew044. Epub 2016 Apr 18.

    Abstract

    Inflammation and oxidative stress are closely related. Further, oxidative stress plays an important role in the pathology of inflammation-based Kawasaki disease. An excessive in vivo production of reactive oxygen species increases oxidative stress in the body, which triggers an endless vicious spiral of inflammation reactions and reactive oxygen metabolites. This presumably forms diffuse vasculitis in the acute phase. Acute inflammation and oxidative stress can be rapidly controlled by treatments; however, they may remain for a long time. This has recently been identified as a problem in the chronic phase of Kawasaki disease. Generally, the presence of vascular inflammation and oxidative stress impairs blood vessels, leading to the onset of atherosclerosis, which is a widely recognized risk. The current discussion focuses on whether the same is valid for blood vessels in the chronic phase of Kawasaki disease.

    Full paper:

    https://academic.oup.com/rheumatolog...56/1/6/2631538

    Interesting to note, IV Vite C showed real promise and is mentioned in the paper above:

    Clinical Investigation

    Evaluation by High-Resolution Ultrasonography of Endothelial Function in Brachial Artery After Kawasaki Disease and the Effects of Intravenous Administration of Vitamin C

    https://www.jstage.jst.go.jp/article...0_908/_article
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  5. #25
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    15,348
    Feedback Score
    5 (100%)
    Good review paper to check out that further supports use of whey, NAC, and other compounds that support GSH production:

    Endogenous deficiency of glutathione as the most likely cause of serious manifestations and death in patients with the novel coronavirus infection (COVID-19): a hypothesis based on literature data and own observations

    Based on an exhaustive literature analysis and own observations, I proposed a hypothesis that glutathione deficiency is exactly the most plausible explanation for serious manifestation and death in COVID-19 infected patients. The major risk factors established for severe COVID-19 infection and relative glutathione deficiency found in COVID-19 infected patients with moderate-to-severe illness have converged me to two very important conclusions: (1) oxidative stress contributes to hyper-inflammation of the lung leading to adverse disease outcomes such as acute respiratory distress syndrome, multiorgan failure and death; (2) poor antioxidant defense due to endogenous glutathione deficiency as a result of decreased biosynthesis and/or increased depletion of GSH is the most probable cause of increased oxidative damage of the lung, regardless which of the factors aging, chronic disease comorbidity, smoking or some others were responsible for this deficit. The hypothesis provides novel insights into the etiology and mechanisms responsible for serious manifestations of COVID-19 infection and justifies promising opportunities for effective treatment and prevention of the illness through glutathione recovering with N-acetylcysteine and reduced glutathione.

    Paper:

    https://www.researchgate.net/publica...re_data_and_ow
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  6. #26
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    15,348
    Feedback Score
    5 (100%)
    An open label study in the works examining NAC and Covid:

    A Study of N-acetylcysteine in Patients With COVID-19 Infection

    Brief Summary:

    The study researchers think that a medication called N-acetylcysteine can help fight the COVID-19 virus by boosting a type of cell in your immune system that attacks infections. By helping your immune system fight the virus, the researchers think that the infection will get better, which could allow the patient to be moved out of the critical care unit or go off a ventilator, or prevent them from moving into a critical care unit or going on a ventilator.

    The US Food and Drug Administration (FDA) has approved N-acetylcysteine to treat the liver side effects resulting from an overdose of the anti-inflammatory medication Tylenol® (acetaminophen). N-acetylcysteine is also used to loosen the thick mucus in the lungs of people with cystic fibrosis or chronic obstructive pulmonary disease (COPD). This study is the first to test N-acetylcysteine in people with severe COVID-19 infections.

    https://clinicaltrials.gov/ct2/show/NCT04374461
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  7. #27
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    15,348
    Feedback Score
    5 (100%)
    Excellent paper on glutathione (GSH) and its importance in Covid infections:

    Endogenous deficiency of glutathione as the most likely cause of serious manifestations and death in patients with the novel coronavirus infection (COVID-19): a hypothesis based on literature data and own observations

    Based on an exhaustive literature analysis and own observations, I proposed a hypothesis that glutathione deficiency is exactly the most plausible explanation for serious manifestation and death in COVID-19 infected patients. The major risk factors established for severe COVID-19 infection and relative glutathione deficiency found in COVID-19 infected patients with moderate-to-severe illness have converged me to two very important conclusions: (1) oxidative stress contributes to hyper-inflammation of the lung leading to adverse disease outcomes such as acute respiratory distress syndrome, multiorgan failure and death; (2) poor antioxidant defense due to endogenous glutathione deficiency as a result of decreased biosynthesis and/or increased depletion of GSH is the most probable cause of increased oxidative damage of the lung, regardless which of the factors aging, chronic disease comorbidity, smoking or some others were responsible for this deficit. The hypothesis provides novel insights into the etiology and mechanisms responsible for serious manifestations of COVID-19 infection and justifies promising opportunities for effective treatment and prevention of the illness through glutathione recovering with N-acetylcysteine and reduced glutathione.

    https://www.researchgate.net/publica...re_data_and_ow
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

Page 3 of 3 FirstFirst 123

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •