Page 2 of 8 FirstFirst 1234 ... LastLast
Results 11 to 20 of 77

Thread: Covid 19: adjuvant approaches etc,

  1. #11
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Another good review of D specific to covid. While D alone is unlikely to be the key to avoiding serious complications of this virus, to be sure, optimal levels are essential as part of host defenses:

    Optimisation of Vitamin D Status for Enhanced Immuno-protection Against Covid-19

    April 2020Irish medical journal 113(4):58

    http://imj.ie/optimisation-of-vitami...inst-covid-19/
    Last edited by WillBrink; 04-14-20 at 08:29.
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  2. #12
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    I discuss N-acetylcysteine (NAC) in my lengthy article linked in OP. This is a small study but the results were promising and other data supports the benefits of keeping GSH elevated with viral infections. This was a small study however, which needs to be kept in mind:

    Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms.

    Human & Experimental Toxicology (2007) 26,697—703

    Abstract

    In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals to the extent that endogenous anti-oxidants are overwhelmed, permitting oxidative cell damage. The present study examined the benefit of the anti-oxidant compound N-acetylcysteine (NAC) in the management of ARDS by measuring patient's intracellular glutathione (inside red blood cells) and extracellular (plasma) anti-oxidant defense biomarkers and outcome.

    Twenty-seven ARDS patients were recruited from the intensive care unit of a teaching Hospital and randomly divided into two groups. Both groups were managed similarly by regular treatments but 17 patients received NAC 150 mg/kg at the first day that followed by 50 mg/kg/day for three days and 10 patients did not receive NAC. Treatment by NAC increased extracellular total anti-oxidant power and total thiol molecules and also improved intracellular glutathione and the outcome of the patients.

    In conclusion, patients with ARDS are in a deficient oxidant—anti-oxidant balance that can get a significant benefit if supplemented with NAC.

    https://journals.sagepub.com/doi/abs...60327107083452
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  3. #13
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Looks like a 10 week clinical examining vite D and Covid in the works. I'm not convinced vite D mono therapy will have a major impact, but it's good to see a controlled examination will take place. The sentence in bold interesting...

    Brief Summary:

    The new outbreak of the SARS-CoV-2 coronavirus is causing an important pandemic affecting a large number of people all-over the world. Vitamin D is a hormone precursor produced by our own body with the help of sunlight which has an important role on adaptive immunity and cellular differentiation, maturation and proliferation of several immune cells. Reduced levels of vitamin D in calves were positioned as the main cause of bovine coronavirus infection in the past. Therefore, it seems plausible that the use of vitamin D as a nutritional ergogenic aid could be a potential intervention to fight against COVID-19 infected patients which remain asymptomatic or which have non-severe and severe symptoms. This study aims to investigate whether the use of vitamin D as an immune modulator agent induces significant improvements of health status and outcomes in non-severe symptomatic patients infected with COVID-19 as well as preventing COVID-19 health deterioration. We hypothesize that vitamin D will significantly improve hard endpoints related to COVID-19 deleterious consequences compared with a usual care control group.

    Source:

    https://clinicaltrials.gov/ct2/show/NCT04334005
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  4. #14
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Balanced summery of NAC and Covid. Data suggestive of benefit, but data is limited:

    N-acetylcysteine: A rapid review of the evidence for effectiveness in treating COVID-19

    https://www.cebm.net/covid-19/n-acet...ting-covid-19/
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  5. #15
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Just published, very much in line with info discussed in the OP article linked. Larger study is needed, but the results are in line with what I'd expected and recommended and in line with existing data:

    Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases.

    Respir Med Case Rep. 2020 Apr 21:101063.


    Abstract
    Purpose:

    Infection with COVID-19 potentially can result in severe outcomes and death from "cytokine storm syndrome", resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia.
    Methods:

    Two patients living in New York City (NYC) with a history of Lyme and tick-borne co-infections experienced a cough and dyspnea and demonstrated radiological findings consistent with novel coronavirus pneumonia (NCP). A trial of 2 g of PO or IV glutathione was used in both patients and improved their dyspnea within 1 h of use. Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms.

    Conclusion:

    Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NFKappaB and addressing "cytokine storm syndrome" and respiratory distress in patients with COVID-19 pneumonia.

    https://www.ncbi.nlm.nih.gov/pubmed/...o0UqaJtJigFqeE
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  6. #16
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Though correlational vs an RCT, makes some sense as "Many of the body's major antioxidant systems have selenoproteins including five glutathione peroxidases." and GSH and others are essential to immunity and dealing with viruses.

    Link identified between dietary selenium and outcome of COVID-19 disease

    An international team of researchers, led by Professor Margaret Rayman at the University of Surrey, has identified a link between the COVID-19 cure rate and regional selenium status in China.

    Publishing their findings in the American Journal of Clinical Nutrition, researchers using data (up to 18 February), investigated possible links between selenium levels in the body and cure or death rates of those with the COVID-19 virus in China.

    Selenium is an essential trace element obtained from the diet (i.e. fish, meat and cereals) which has been found to affect the severity of a number of viral diseases in animals and humans. For example selenium status in those with HIV has been shown to be an important factor in the progression of the virus to AIDs and death from the condition. China is known to have populations that have both the lowest and highest selenium status in the world, due to geographical differences in the soil which affects how much of the trace element gets into the food chain.

    Margaret Rayman, Professor of Nutritional Medicine at the University of Surrey, said: "Given the history of viral infections associated with selenium deficiency, we wondered whether the appearance of COVID-19 in China could possibly be linked to the belt of selenium deficiency that runs from the north-east to the south-west of the country."

    Examining data from provinces and municipalities with more than 200 cases and cities with more than 40 cases, researchers found that areas with high levels of selenium were more likely to recover from the virus. For example, in the city of Enshi in Hubei Province, which has the highest selenium intake in China, the cure rate (percentage of COVID-19 patients declared 'cured') was almost three-times higher than the average for all the other cities in Hubei Province. By contrast, in Heilongjiang Province, where selenium intake is among the lowest in the world, the death rate from COVID-19 was almost five-times as high as the average of all the other provinces outside of Hubei.

    Most convincingly, the researchers found that the COVID-19 cure rate was significantly associated with selenium status, as measured by the amount of selenium in hair, in 17 cities outside of Hubei.

    Kate Bennett, a medical statistician at the University of Surrey, said; "There is a significant link between selenium status and COVID-19 cure rate, however it is important not to overstate this finding; we have not been able to work with individual level data and have not been able to take account of other possible factors such as age and underlying disease."
    Ramy Saad, a doctor at Royal Sussex County Hospital, Brighton, currently taking an MSc degree in Nutritional Medicine at the Department of Nutritional Sciences at Surrey, commented; "The correlation we have identified is compelling, particularly given previous research on selenium and infectious diseases. As such, a careful and thorough assessment of the role selenium may play in COVID-19 is certainly justified and may help to guide ongoing public-health decisions."

    Source:

    https://www.sciencedaily.com/release...0429105907.htm
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  7. #17
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Potentially important finding here, but while the correlation was strong, cause and effect conclusions should not be made from such findings alone:

    COVID-19 Deaths Are Being Linked to Vitamin D Deficiency. Here's What That Means

    A vitamin commonly produced by sun-exposed skin cells might play a role in preventing death by the coronavirus SARS-CoV-2, according to new research.

    Preliminary results from a yet-to-be-peer-reviewed study carried out by scientists from the Queen Elizabeth Hospital Foundation Trust and the University of East Anglia have linked low levels of the hormone vitamin D with COVID-19 mortality rates across Europe.

    It's a study that certainly deserves some attention as a potential piece of the coronavirus puzzle, reminding us that health and disease can be a complex affair involving a variety of lifestyle factors.

    But it's also important to interpret evidence like this as part of a bigger scientific conversation, meaning it would be premature to make any recommendations and certainly way too premature to hit the supplement aisle before further evidence arrives.

    The researchers dug through existing health literature to catalogue the average levels of vitamin D among the citizens of 20 European countries, and then compared the figures with the relative numbers of COVID-19 deaths in each country.

    A simple statistical test showed there was a pretty convincing correlation between the figures, where populations with lower than average concentrations of the vitamin also featured more deaths from SARS-CoV-2.

    "The most vulnerable group of population for COVID-19 is also the one that has the most deficit in vitamin D," the researchers conclude in their preliminary report.

    Cont:

    https://www.sciencealert.com/covid-d...at-that-means/

    Source report:

    https://www.researchsquare.com/article/rs-21211/v1
    Last edited by WillBrink; 05-03-20 at 12:07.
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  8. #18
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Vite D status a risk factor for severity of Covid?

    Chest clinic: Basic science for the chest physician
    Vitamin D and lung disease

    Abstract

    The classic role of vitamin D in the regulation of calcium and phosphate metabolism, and its effects on bone health, are well established. More recently a critical role in immunity and respiratory health has been proposed. This arises from evidence for the capacity to generate the active metabolite, 1α,25-dihydroxyvitamin D3 (1,25(OH)D3), locally in many tissues beyond the kidney; expression of the vitamin D receptor (VDR) in immune and structural cells not involved in calcium-phosphate homeostasis; and control by 1,25(OH)D3 of the transcription of genes associated with numerous different biological processes through its nuclear VDR. Abnormalities in the vitamin D axis, including a high prevalence of vitamin D insufficiency worldwide, now appear important in a wide range of pulmonary diseases including viral and bacterial respiratory infection, asthma, chronic obstructive pulmonary disease, and cancer. Actions of vitamin D on innate immune responses, for example, production of antimicrobial peptides and autophagy, and on adaptive immune responses, for example, promoting regulatory lymphocytes, are believed to underpin these associations.

    Cont:

    https://thorax.bmj.com/content/67/11/1018.full
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  9. #19
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    While we need more data, there's no doubt in my mind IV vite C is of benefit in various medical conditions, and of course very relevant to the current situation with Covid. I discuss that and other potential treatments in OP linked article. This is a very dramatic case where vite C seemingly saved a life. It's a vid, so obviously does not replace objective data, but case studies like this have their place too:


    Last edited by WillBrink; 05-08-20 at 10:30.
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  10. #20
    Join Date
    Feb 2009
    Location
    Florida
    Posts
    16,949
    Feedback Score
    5 (100%)
    Folks, case study on the use of GSH therapy and Covid. For a case study, is a long and detailed write up:

    Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

    Respiratory Medicine Case Reports
    Volume 30, 2020, 101063

    Abstract

    Purpose

    Infection with COVID-19 potentially can result in severe outcomes and death from “cytokine storm syndrome”, resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia.

    Methods

    Two patients living in New York City (NYC) with a history of Lyme and tick-borne co-infections experienced a cough and dyspnea and demonstrated radiological findings consistent with novel coronavirus pneumonia (NCP). A trial of 2 g of PO or IV glutathione was used in both patients and improved their dyspnea within 1 h of use. Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms.

    Conclusion

    Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NF-κB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia.

    Full paper:

    https://www.sciencedirect.com/scienc...13007120301350
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

Page 2 of 8 FirstFirst 1234 ... LastLast

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •