I would rather shoot a moose or elk with a 140-156-gr bonded (e.g. Nosler AccuBond, Norma Oryx) 6.5mm/.264" bullet than with anything available in .277".
I do not believe that bullets of such weight are available loaded for 6.5mm Grendel and, moreover, I'm reasonably certain that given the Grendel's short cartridge case, it would not be possible to load them without severely reducing the powder capacity of the cartridge.
Given the success many old school local hunters have had with 22-250s loaded with 60-gr Nosler Partitions in humanely harvesting elk, I can think of no reason why a 5.56mm rifle loaded with similar traditional bullets (Nosler Partitions and Swift A-Frames) or more modern bonded and all-copper bullets (Speer Gold Dot/Federal Fusion, Hornady GMX, Barnes TTSX/TSX) could not be used to similar effect.
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