Met has an exceptional safety record. Do you have a source on that one? It is indeed about as close to a wonder drug as exists in terms of risk/benefit and I have not seen data that it's nephrotoxic at therapeutic doses used in studies, of which there are many. In some specific patient populations, there are possible contraindications, and per usual in that population, risk/benefit needs to be assessed.
There appears to benefits even for those with CKD:
https://www.niddk.nih.gov/health-inf...kidney-disease
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