Per above, latest thinking on that is via NIH page and it's changed some, but as I said, contraindications always exist. The way you had worded it would lead someone to think it's nephrotoxic, and that is not the case. Under specific circumstances/patient populations, it may not be the best choice, but even in those populations, latest data seems to be changing on that too. Old warnings were based on creatinine levels, which is a poor indicator at best, FDA has changed it's position in fact as new data came out:
"We have concluded from the review of studies published in the medical literature that metformin can be used safely in patients with mild impairment in kidney function and in some patients with moderate impairment in kidney function.3-6 We are requiring changes to the metformin labeling to reflect this new information and provide specific recommendations on the drug’s use in patients with mild to moderate kidney impairment."
https://www.fda.gov/drugs/drug-safet...formin-certain
In terms of the OP, in healthy people using it for anti aging / longevity, there's no reason to worry about kidney issues.
Ivermectin
is a wonder drug (hence the Nobel Prize), it's just not a wonder drug for curing covid.
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