Originally Posted by
WillBrink
If you were without any sci/med background and or knowledge of met, and read the opening sentence "Ironically, it can be bad for the renal system and cause renal failure." would indicate to a reader the drug in inherently toxic to the kidneys, no? That's how I would read it. And, per modern recs from FDA etc, it's now not even contraindicated for those with mild/moderate CKD and the prior warnings no longer accurate apparently.
In very rare cases, in specific diabetic populations, with severe CKD, it can cause acidosis, and that appears about it, which of course has no bearing on those the OP article is aimed at.
I agree that we may not see it go very far off-formulary, but you'd be surprised how many docs are giving to patients that are not diebetics, and of course the concept of preemptive anti aging medicine and approaches are a foreign concept to most med pros. That too is changing. FYI, Met is the first drug for FDA’s approval of the first human study to see if metformin can protect against the multiple diseases of aging.
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