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Thread: Got Testosterone?

  1. #1081
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    Quote Originally Posted by CheapBrake634 View Post
    I really need this information, because I want to get to Fit Stream in a year, competitions .... and the form has not been formed for 3 years already enough ... I don’t know what to do ... I was advised to try the tester with T-boost
    Basics are, you get tested to see if you're a candidate for TRT, and proceed from there, working with your doc. OTC "T boosters" are a waste of money.
    - Will

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    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  2. #1082
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    More reasons to limit those nsaids boys! use of nsaids may be one of various factors we have seen a drop in T levels in men over the past decades. Use them sparing and only as needed:

    Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

    PNAS January 23, 2018 115 (4) E715-E724;

    Significance

    Concern has been raised over declining male reproductive health in humans. Our study addresses this issue by extending data showing antiandrogen effects of analgesics and suggests that such compounds may be involved in adult male reproductive problems. Using a unique combination of a randomized, controlled clinical trial and ex vivo and in vitro approaches, we report a univocal depression of important aspects of testicular function, including testosterone production, after use of over-the-counter ibuprofen. The study shows that ibuprofen use results in selective transcriptional repression of endocrine cells in the human testis. This repression results in the elevation of the stimulatory pituitary hormones, resulting in a state of compensated hypogonadism, a disorder associated with adverse reproductive and physical health disorders.

    https://www.pnas.org/content/115/4/E...dP2h_gn5Wma_fE
    - Will

    General Performance/Fitness Advice for all

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    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  3. #1083
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    Well, that's interesting. I was popping ibuprofen like candy for many years after injuring my lower back...

  4. #1084
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    So, we come full circle to T potentially being used to treat some forms of prostate cancers:

    "Rationale for Using Supraphysiologic Testosterone to Treat Castration-Resistant Prostate Cancer.”

    We have known for decades that androgen deprivation offers remarkable efficacy and palliation for men with advanced prostate cancer. Yet, soon after Charles Huggins Nobel Prize-winning discovery, many case series started emerging, describing paradoxical benefits of testosterone supplementation for patients with prostate cancer.1,2 These clinical observations seem so counterintuitive given that androgen deprivation therapy is the hallmark of treatment for advanced prostate cancer. Yet, there may be supportive biological rationale to this surprising observation.

    Cont:

    https://www.urotoday.com/clinical-tr...yDJb1V8O1o_wWk
    - Will

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    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

  5. #1085
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    Important study finding here. Those on T did not go onto type II diabetes, had lower rates of CVD, etc compared to untreated:

    Testosterone Therapy in Men With Hypogonadism Prevents Progression From Prediabetes to Type 2 Diabetes: Eight-Year Data From a Registry Study

    Abstract

    OBJECTIVE Type 2 diabetes (T2D) is a public health threat. Prediabetes represents a window of opportunity for intervention to prevent T2D. Men with T2D and prediabetes often have low testosterone. Since testosterone improves glycemic control in T2D, we investigated whether testosterone therapy (TTh) in men with hypogonadism and prediabetes prevents progression to T2D.

    RESEARCH DESIGN AND METHODS Three hundred sixteen men with prediabetes (defined as HbA1c 5.7–6.4%) and total testosterone levels ≤12.1 nmol/L combined with symptoms of hypogonadism were analyzed. Two hundred twenty-nine men received parenteral testosterone undecanoate (T-group), and 87 men with hypogonadism served as untreated control subjects. Metabolic and anthropometric parameters were measured twice yearly for 8 years.

    RESULTS HbA1c decreased by 0.39 ± 0.03% (P < 0.0001) in the T-group and increased by 0.63 ± 0.1% (P < 0.0001) in the untreated group. In the T-group, 90% achieved normal glucose regulation (HbA1c <5.7%). In the untreated group, 40.2% progressed to T2D (HbA1c >6.5%). TTh was also associated with significant improvements in fasting glucose, triglyceride:HDL ratio, triglyceride-glucose index, lipid accumulation product, total cholesterol, LDL, HDL, non-HDL, triglycerides, and Aging Males’ Symptoms (AMS) scale. Significant deterioration in all these parameters was seen in the untreated group. Mortality was 7.4% in the T-group and 16.1% in the untreated group (P < 0.05). The incidence of nonfatal myocardial infarction was 0.4% in the T-group and 5.7% in the untreated group (P < 0.005).

    CONCLUSIONS Long-term TTh completely prevents prediabetes progression to T2D in men with hypogonadism and improves glycemia, lipids, and AMS score. TTh holds tremendous potential for the large and growing population of men with prediabetes and hypogonadism.

    cont;

    http://care.diabetesjournals.org/con...JktHA7ytYOuS3Y
    - Will

    General Performance/Fitness Advice for all

    www.BrinkZone.com

    Performance/Fitness Advice For the Tactical Community

    www.OptimalSWAT.com


    “Those who do not view armed self defense as a basic human right, ignore the mass graves of those who died on their knees at the hands of tyrants.”

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