For my .02, I would stick with a 5.56 and use some 75 gr ammo in it. But if you insist on something with more punch, Alexander Arms makes complete uppers that fire a .50 cal Beowulf round. Basically, it's similar to a .500 S&W but with a rimless case. You really sacrifice magazine capacity with that thing, but it is a devastating round under 200 yards. The drawbacks are increased recoil, very expensive ammo, and 10 rounds as opposed to 30 in the mag.
But to add weight to what has been said before, a big caliber doesn't make up for poor marksmanship. 1,000:1 I would rather have a well-trained man with a 5.56 using M-193 covering my back than a poorly trained man with the .50 cal Beowulf.
I certainly mean no disrespect when I say any of the above statements. I honor your desire to have the most effective weapon to defend your home, but a reliable 5.56 in the hands of a well-trained person is a devastatingly leathal combination.
Ted Kennedy's car has killed more people than my AR.
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