As a fellow lefty
Ive been running Crimson trace grips on one of my 1911s for about a year now, with approx 2000 rounds though it since ive learned to drop my thumb if I want to use them. I dont see the laser as a primary aiming device though. I see it as an emergency aiming device, and rarely use them under normal condidions. If im shooting normal my high thumb grip covers the beam, but if I am one handed or reaction hand shooting they work great. The one real complaint I have about them is they limit the size of the left side safety to about 1/3 its full size. With training I can work it but when I go to my other 1911 with a full size one I feel much better.
I now would rather have something like an x400 because it does not add that much weight compared to a x300 im currently running.
Or you could try looking into this, not my cup of tea but could solve your needs.

http://www.laserlyte.com/
"If you're not shootin', you should be loadin'. If you're not loadin, you should be movin', if you're not movin', someone's gonna cut your head off and put it on a stick."
-Clint Smith
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