No.

There is no handgun round that liquifies internals. .44 mag is no more effective on bad guys than any other service-grade caliber. They all make holes that cause death by exsanguination. 9mm does the same thing. Hit the vitals, they croak. Miss the vitals, they don't.

Different story with 1000 pound brown bears. There, you need much more penetration to get to the vitals.