If you have to ask the answer is no.

I think you have to like reloading and tweaking ammo or know you want the benefits of more power, more range or what ever for the nonstandard AR calibers to be worth it. They are just a bigger pain in the ass than 5.56. But I do like my Grendel it's been worth ever penny.

For what you want to do with it the 300 Blackout looks like something you should consider. Using 5.56 mags is a real plus.