I see very little reason for purchasing a .22 M&P M4 clone as opposed to a 5.56. Other then cost all you are doing is purchasing an inferior replica of a tool that was designed to function in a certain way, for a certain purpose.
I've grown up with firearms and been taught that ALL firearms are equal in that they can kill you, or destroy what the muzzle is pointed at, regardless of caliber. This is absolute truth, therefore making decisions on "lesser calibers" for the purpose of anything other then cost, and recoil is pointless. You have already stated that cost is not an issue, and since the 5.56 M4 has literally no recoil worth mentioning if shot properly there is not a choice to be made. Go with the caliber the system was designed for. It's not like since it's a bigger caliber it's going to jump up and bite you or something.
I've seen these questions pop up from time to time, and I always scratch my head. Do you mind telling me why exactly you are even considering the options?
Mobocracy is alive and well in America.*
*Supporting Evidence for Hypothesis: The Internet
-me
'All of my firearms have 4 military features, a barrel, a trigger, a hammer, and a stock."
-coworker
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