My experience with actually shooting anything alive with buckshot was at a hog. I used Federal 2 3/4", 00 Copper Plated lead Buckshot from a 26" Benelli SBE at about 30 yards.
It did the trick and then some, full pass through. I got lucky and killed a babie piggie behind the sow too all in one shot. I found one of the balls embeded in the sow's opposite shoulder from where I shot her, and the entire weight of the ball seemd to still be there, fully intact, just wadded and flattened.
So, I have full confidence in that round to deliver similar results if ever needed to defend against an intruder. Just do your part, hit where you want and I feel any 00 buck will be simply devestating, especially considering home defense ranges.
But from what I have gathered, the only advantages of 3" and 3 1/2" shells are more shot. They deliver the same velocities as 2 3/4" shells and therefore same knock down power ball for ball. In a house, if you can make 12 balls hit your target, you can make 9 balls hit your target, with less recoil and more room in the mag.
The only stuff I stay away from is Winchester shells. They always get that white powder crap all over the place form the shell not being fully closed.
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