As to top break revolvers, S & W had a modern, limited run quite a while ago and they sold out quickly. I would not use one for self defense. The cowboy guns are not suitable for my needs either, but they are fun.
The fastest speed loader around is Jerry Miculek with his moon clipped S & W. I have not found a practical way to carry moon clips concealed. Most belt holders are designed for competition and are very bulky.
I don't see that you have a problem at all. Unless you are truly ambidextrous, you will have faster reloads manipulating the rounds with the strong hand VS the support hand. You have to "break" your grip.
Maintaining a firing grip is a moot point on a revolver with the cylinder swung open. It can't fire. Here is a good video showing the evolution of revolver speed loads. At 4:44 there is a good demo of left handed reloads on "right handed" revolvers. It may actually work well for you since the work space is right in front of you on your dominant side.
Speed strips are a little different since you will be more than likely "topping off" a few rounds when you can grab cover, rather than a full reload. They require more dexterity to use than a speed loader in my opinion.
http://www.youtube.com/watch?NR=1&v=oXUwI_d8JlA
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