I use a 50yd zero (start at 25yds getting it good windage wise, and hitting 1" low) then move to 50yds and get it to hit POA/POI.
The absolute best way is to measure your sight height over bore, chrono your load and find the ballistic coefficient of your projectiles and plug these numbers into a ballistics calculator and find the flattest trajectory playing with the sight in distance, use a max range of 250-300yds.
I use this ballistics calculator http://www.handloads.com/calc/index.html
Chief Armorer for Elite Shooting Sports in Manassas VA
Chief Armorer for Corp Arms (FFL 07-08/SOT 02)
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