I have a 686 with a 4" barrel. I shoot it very well. I feel comfortable using it for home defense or as a walk in the wood gun. Like other have said more velocity and longer site radius in the 6" barrel. either would work as a home defense gun. I think you happy with either. For home defense you either use what you have or get something that is specif to the roll. I can not tell you what to use for home defense, everyone has a pet gun for the roll. You know your house you know the strong point and weak point of the best places to defend your home.
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